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[Frenchfry]

No one has yet reported damage to their engine from acetone being added to the fuel.

The fact that they crossed that statement out is cause for concern as well as these other quotes derived from your link:

Acetone is known to deteriorate cheap plastics and other substances. While the components in a car's fuel system should be of high quality, and thus immune to any deleterious effects from exposure to acetone, be aware that "ideal" is not always the case in practice. Be advised that not all systems have been tested against acetone. Until such thorough testing has been accomplished and certified by an accredited authority, you assume your own liability for experimentally testing acetone in your particular system.

Some who have tried soaking fuel component in pure acetone have noted a slight swelling of some components. Noting that, someone posted the following:
"Swelling of fuel system components listed as 'adverse effects' indicates a chemical reaction and is potentially dangerous

As a former mechanic I found this experiment to be of great interest. I was unfortunately a victim to the early testimony here that said acetone does not harm engine parts.
I added acetone as recommended to both my 1996 Honda Accord wagon and saw increased miles right away. I also put it in my 1997 Dodge Ram 1500. After several tanks in my truck (and a little better mileage) I found my number 1 injector showed up as failing. Shortly after that I was talking to John Bedini about the better mileage I was getting and then he said, "yeah, but it will kill your injectors." Then I laughed and told him this just happened to me.
So this weekend I went up to the cottage and my Honda would not start again. Had to tow it home 100 miles and go home early. Turns out my fuel pump was gone. The mechanic asked me, have you used injector cleaner in your car? I told him about the Acetone. He said, Honda pumps never go unless you damage them like this.
So I conclude that this added mileage is certainly not worth the damage it causes. And I suspect that we only read the initial reports here and not the long haul uses of acetone.
Be warned.

http://peswiki.com/index.php/Directory:Acetone_as_a_Fuel_Additive#Damages_Fuel_Injectors_and_Fuel_Pumps
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[ChadB]

I've been wondering about adding some model airplane fuel to my gas...I'm pretty sure that stuff is nitro methane. I ran a go kart on that when I was a kid....that little 5 hp briggs and stratton was running SWEET, until it shot the connecting rod right out of the block.

[www.BarackObama.com]

I conducted another experiment this weekend.

Driving 70 miles each way at 55MPH while pulling a 4800lb RV and 8 passengers in my Expedition I was getting 7.6 mpg. Before I left the campground to come home I added 3oz of acetone to the 10 gallons of gas I had left in the tank and drove to Kroger once and then hooked up the trailer for the return trip. For the trip home, it was about 15 degrees colder on the trip home, so that would cause a slightly richer fule mixture (meaning that if it were the same temperature, the "with acetone" mileage would be slightly higher) but I was still able to get 10.7 mpg on the way home. That was an increase of 40.78%.

I was totally blown away! No pictures of the dashboard, but what reason do I have to make it up.

My friend has been adding 2oz to every 10 gallons on his 2008 GMC 4 door pickup and his combined hwy/city average has gone up to 18.9 mpg, that's about 24% increase. He is going to try 3oz per 10 gallons, and I will give an update after his testing. I will also try to get him to do a hwy test at 55 and 70MPH.

[T-M-T]

I conducted another experiment this weekend.

Driving 70 miles each way at 55MPH while pulling a 4800lb RV and 8 passengers in my Expedition I was getting 7.6 mpg. Before I left the campground to come home I added 3oz of acetone to the 10 gallons of gas I had left in the tank and drove to Kroger once and then hooked up the trailer for the return trip. For the trip home, it was about 15 degrees colder on the trip home, so that would cause a slightly richer fule mixture (meaning that if it were the same temperature, the "with acetone" mileage would be slightly higher) but I was still able to get 10.7 mpg on the way home. That was an increase of 40.78%.

I was totally blown away! No pictures of the dashboard, but what reason do I have to make it up.

My friend has been adding 2oz to every 10 gallons on his 2008 GMC 4 door pickup and his combined hwy/city average has gone up to 18.9 mpg, that's about 24% increase. He is going to try 3oz per 10 gallons, and I will give an update after his testing. I will also try to get him to do a hwy test at 55 and 70MPH.

I'd be interested to see a longer-term test.  As a scientist, it is very difficult for me to believe that adding two-tenths of a percent of a solvent to your gasoline would net such a huge gain in the energy produced by that gasoline.  I'm not saying you are wrong, I'm just very skeptical.  Keep us updated on further testing.

Googling "acetone in gasoline" seems to show a lot of evidence that the claims of better mileage are more anecdotal than research-based.

Some info from snopes.com:  http://www.snopes.com/autos/techno/acetone.asp

Snopes is actually a little misleading in saying that acetone is corrosive.  While not corrosive, acetone has solvent properties that gasoline does not have and could wreak havoc on rubber and plastic parts.